P61247: 40S ribosomal protein S3a {ECO:0000255|HAMAP-Rule:MF_03122}

General Information

Protein names	- 40S ribosomal protein S3a {ECO:0000255\|HAMAP-Rule:MF_03122} - Small ribosomal subunit protein eS1 {ECO:0000303\|PubMed:24524803} - v-fos transformation effector protein - Fte-1
Gene names	RPS3A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P61247

26 N-termini

21 C-termini

14 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAVGKNKRLT KGGKKGAKKK VVDPFSKKDW YDVKAPAMFN IRNIGKTLVT RTQGTKIASD
        70         80         90        100        110        120
GLKGRVFEVS LADLQNDEVA FRKFKLITED VQGKNCLTNF HGMDLTRDKM CSMVKKWQTM
       130        140        150        160        170        180
IEAHVDVKTT DGYLLRLFCV GFTKKRNNQI RKTSYAQHQQ VRQIRKKMME IMTREVQTND
       190        200        210        220        230        240
LKEVVNKLIP DSIGKDIEKA CQSIYPLHDV FVRKVKMLKK PKFELGKLME LHGEGSSSGK
       250        260
ATGDETGAKV ERADGYEPPV QESV

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

26 N-termini - 21 C-termini - 14 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P61247-2-unknown	AVGKNK...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P61247-2-unknown	AVGKNK...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P61247-2-unknown	AVGKNK...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P61247-6-unknown	NKRLTK...	6	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000421457
P61247-7-unknown	KRLTKG...	7	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000425508
P61247-19-unknown	KKVVDP...	19	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14235
P61247-19-unknown	KKVVDP...	19	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11744
P61247-21-	VVDPFS...	21		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P61247-21-	VVDPFS...	21		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P61247-21-	VVDPFS...	21		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P61247-31-unknown	YDVKAP...	31	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11745
P61247-38-unknown	MFNIRN...	38	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000425024
P61247-38-unknown	MFNIRN...	38	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000421770
P61247-38-unknown	MFNIRN...	38	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000421277
P61247-38-unknown	MFNIRN...	38	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000421776
P61247-38-unknown	MFNIRN...	38	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000424547
P61247-38-unknown	MFNIRN...	38	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000426282
P61247-52-	TQGTKI...	52		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P61247-52-unknown	TQGTKI...	52	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10116
P61247-53-unknown	QGTKIA...	53	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10117
P61247-61-unknown	GLKGRV...	61	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11746
P61247-66-unknown	VFEVSL...	66	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10118
P61247-68-unknown	EVSLAD...	68	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10119
P61247-70-	SLADLQ...	70		Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P61247-72-	ADLQND...	72		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P61247-72-unknown	ADLQND...	72		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P61247-74-unknown	LQNDEV...	74	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11747
P61247-83-unknown	KFKLIT...	83	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10120
P61247-99-unknown	NFHGMD...	99	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7614
P61247-120-unknown	MIEAHV...	120	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000422994
P61247-154-unknown	SYAQHQ...	154	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14236
P61247-168-	MMEIMT...	168		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P61247-168-	MMEIMT...	168		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P61247-223-	FELGKL...	223		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P61247-228-	LMELHG...	228		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P61247-232-unknown	HGEGSS...	232	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14237
P61247-241-	ATGDET...	241		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...KKGAKK	18	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14235
...KKGAKK	18	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11744
...SKKDWY	30	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11745
...TLVTRT	51	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10116
...LVTRTQ	52	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10117
...KIASDG	60	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11746
...GLKGRV	65	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10118
...KGRVFE	67	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10119
...VSLADL	73	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11747
...EVAFRK	82	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10120
...KNCLTN	98	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7614
...TNFHGM	102	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000421277
...LLRLFC	138	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000425024
...QIRKTS	153	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14236
...HQQVRQ	162	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000421776
...VVNKLI	188	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000444951
...GKLMEL	230	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000424547
...KLMELH	231	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14237
...GKATGD	243	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000426466
...PPVQES	262	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11748
...VQESV	264		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...VQESV	264		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...VQESV	264	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...VQESV	264		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...VQESV	264		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	18	GAKK.\|.KKVV	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	18	GAKK.\|.KKVV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	30	KDWY.\|.YDVK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAA_HUMAN	51	VTRT.\|.TQGT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAA_HUMAN	52	TRTQ.\|.QGTK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAB_HUMAN	60	ASDG.\|.GLKG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAA_HUMAN	65	KGRV.\|.VFEV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAA_HUMAN	67	RVFE.\|.EVSL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAB_HUMAN	73	LADL.\|.LQND	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAA_HUMAN	82	AFRK.\|.KFKL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
CATS_HUMAN	98	CLTN.\|.NFHG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	153	RKTS.\|.SYAQ	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	231	MELH.\|.HGEG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	262	VQES.\|.SV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)