Q02790: Peptidyl-prolyl cis-trans isomerase FKBP4

General Information

Protein names	- Peptidyl-prolyl cis-trans isomerase FKBP4 - PPIase FKBP4 - 5.2.1.8 - 51 kDa FK506-binding protein - FKBP51 - 52 kDa FK506-binding protein - 52 kDa FKBP - FKBP-52 - 59 kDa immunophilin - p59 - FK506-binding protein 4 - FKBP-4 - FKBP59 - HSP-binding immunophilin - HBI - Immunophilin FKBP52 - Rotamase - Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed
Gene names	FKBP4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q02790

13 N-termini

5 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MTAEEMKATE SGAQSAPLPM EGVDISPKQD EGVLKVIKRE GTGTEMPMIG DRVFVHYTGW
        70         80         90        100        110        120
LLDGTKFDSS LDRKDKFSFD LGKGEVIKAW DIAIATMKVG EVCHITCKPE YAYGSAGSPP
       130        140        150        160        170        180
KIPPNATLVF EVELFEFKGE DLTEEEDGGI IRRIQTRGEG YAKPNEGAIV EVALEGYYKD
       190        200        210        220        230        240
KLFDQRELRF EIGEGENLDL PYGLERAIQR MEKGEHSIVY LKPSYAFGSV GKEKFQIPPN
       250        260        270        280        290        300
AELKYELHLK SFEKAKESWE MNSEEKLEQS TIVKERGTVY FKEGKYKQAL LQYKKIVSWL
       310        320        330        340        350        360
EYESSFSNEE AQKAQALRLA SHLNLAMCHL KLQAFSAAIE SCNKALELDS NNEKGLFRRG
       370        380        390        400        410        420
EAHLAVNDFE LARADFQKVL QLYPNNKAAK TQLAVCQQRI RRQLAREKKL YANMFERLAE
       430        440        450
EENKAKAEAS SGDHPTDTEM KEEQKSNTAG SQSQVETEA

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

13 N-termini - 5 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q02790-1-Acetylation	MTAEEM...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q02790-1-Acetylation	MTAEEM...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q02790-2-Acetylation	TAEEMK...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q02790-2-Acetylation	TAEEMK...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q02790-2-	TAEEMK...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q02790-2-	TAEEMK...	2			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q02790-2-	TAEEMK...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q02790-2-	TAEEMK...	2			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q02790-2-	TAEEMK...	2			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q02790-2-	TAEEMK...	2			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q02790-2-	TAEEMK...	2			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q02790-2-unknown	TAEEMK...	2			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q02790-2-unknown	TAEEMK...	2			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q02790-2-unknown	TAEEMK...	2			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q02790-6-	MKATES...	6			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q02790-6-	MKATES...	6			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q02790-15-	SAPLPM...	15			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q02790-15-	SAPLPM...	15			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q02790-15-	SAPLPM...	15			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q02790-15-	SAPLPM...	15			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q02790-15-	SAPLPM...	15			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q02790-15-	SAPLPM...	15			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q02790-16-unknown	APLPME...	16		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17834
Q02790-46-unknown	MPMIGD...	46		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000446368
Q02790-109-unknown	PEYAYG...	109		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q02790-113-unknown	YGSAGS...	113		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3954
Q02790-263-	SEEKLE...	263			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q02790-304-unknown	SSFSNE...	304		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7725
Q02790-409-	KLYANM...	409			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SGAQSA	15	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17834
...KPEYAY	112	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3954
...TLVFEV	131	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000446368
...WLEYES	303	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7725
...VETEA	459	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	15	AQSA.\|.APLP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATB_HUMAN	112	EYAY.\|.YGSA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	303	EYES.\|.SSFS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)