P27708: CAD protein
Protein names | - CAD protein - Glutamine-dependent carbamoyl-phosphate synthase - 6.3.5.5 {ECO:0000269|PubMed:24332717} - Aspartate carbamoyltransferase - 2.1.3.2 {ECO:0000269|PubMed:24332717} - Dihydroorotase - 3.5.2.3 {ECO:0000269|PubMed:24332717} |
---|---|
Gene names | CAD |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P27708 |
11
N-termini
11
C-termini
8
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MAALVLEDGS VLRGQPFGAA VSTAGEVVFQ TGMVGYPEAL TDPSYKAQIL VLTYPLIGNY
70 80 90 100 110 120
GIPPDEMDEF GLCKWFESSG IHVAALVVGE CCPTPSHWSA TRTLHEWLQQ HGIPGLQGVD
130 140 150 160 170 180
TRELTKKLRE QGSLLGKLVQ NGTEPSSLPF LDPNARPLVP EVSIKTPRVF NTGGAPRILA
190 200 210 220 230 240
LDCGLKYNQI RCLCQRGAEV TVVPWDHALD SQEYEGLFLS NGPGDPASYP SVVSTLSRVL
250 260 270 280 290 300
SEPNPRPVFG ICLGHQLLAL AIGAKTYKMR YGNRGHNQPC LLVGSGRCFL TSQNHGFAVE
310 320 330 340 350 360
TDSLPADWAP LFTNANDGSN EGIVHNSLPF FSVQFHPEHQ AGPSDMELLF DIFLETVKEA
370 380 390 400 410 420
TAGNPGGQTV RERLTERLCP PGIPTPGSGL PPPRKVLILG SGGLSIGQAG EFDYSGSQAI
430 440 450 460 470 480
KALKEENIQT LLINPNIATV QTSQGLADKV YFLPITPHYV TQVIRNERPD GVLLTFGGQT
490 500 510 520 530 540
ALNCGVELTK AGVLARYGVR VLGTPVETIE LTEDRRAFAA RMAEIGEHVA PSEAANSLEQ
550 560 570 580 590 600
AQAAAERLGY PVLVRAAFAL GGLGSGFASN REELSALVAP AFAHTSQVLV DKSLKGWKEI
610 620 630 640 650 660
EYEVVRDAYG NCVTVCNMEN LDPLGIHTGE SIVVAPSQTL NDREYQLLRQ TAIKVTQHLG
670 680 690 700 710 720
IVGECNVQYA LNPESEQYYI IEVNARLSRS SALASKATGY PLAYVAAKLA LGIPLPELRN
730 740 750 760 770 780
SVTGGTAAFE PSVDYCVVKI PRWDLSKFLR VSTKIGSCMK SVGEVMGIGR SFEEAFQKAL
790 800 810 820 830 840
RMVDENCVGF DHTVKPVSDM ELETPTDKRI FVVAAALWAG YSVDRLYELT RIDRWFLHRM
850 860 870 880 890 900
KRIIAHAQLL EQHRGQPLPP DLLQQAKCLG FSDKQIALAV LSTELAVRKL RQELGICPAV
910 920 930 940 950 960
KQIDTVAAEW PAQTNYLYLT YWGTTHDLTF RTPHVLVLGS GVYRIGSSVE FDWCAVGCIQ
970 980 990 1000 1010 1020
QLRKMGYKTI MVNYNPETVS TDYDMCDRLY FDEISFEVVM DIYELENPEG VILSMGGQLP
1030 1040 1050 1060 1070 1080
NNMAMALHRQ QCRVLGTSPE AIDSAENRFK FSRLLDTIGI SQPQWRELSD LESARQFCQT
1090 1100 1110 1120 1130 1140
VGYPCVVRPS YVLSGAAMNV AYTDGDLERF LSSAAAVSKE HPVVISKFIQ EAKEIDVDAV
1150 1160 1170 1180 1190 1200
ASDGVVAAIA ISEHVENAGV HSGDATLVTP PQDITAKTLE RIKAIVHAVG QELQVTGPFN
1210 1220 1230 1240 1250 1260
LQLIAKDDQL KVIECNVRVS RSFPFVSKTL GVDLVALATR VIMGEEVEPV GLMTGSGVVG
1270 1280 1290 1300 1310 1320
VKVPQFSFSR LAGADVVLGV EMTSTGEVAG FGESRCEAYL KAMLSTGFKI PKKNILLTIG
1330 1340 1350 1360 1370 1380
SYKNKSELLP TVRLLESLGY SLYASLGTAD FYTEHGVKVT AVDWHFEEAV DGECPPQRSI
1390 1400 1410 1420 1430 1440
LEQLAEKNFE LVINLSMRGA GGRRLSSFVT KGYRTRRLAA DFSVPLIIDI KCTKLFVEAL
1450 1460 1470 1480 1490 1500
GQIGPAPPLK VHVDCMTSQK LVRLPGLIDV HVHLREPGGT HKEDFASGTA AALAGGITMV
1510 1520 1530 1540 1550 1560
CAMPNTRPPI IDAPALALAQ KLAEAGARCD FALFLGASSE NAGTLGTVAG SAAGLKLYLN
1570 1580 1590 1600 1610 1620
ETFSELRLDS VVQWMEHFET WPSHLPIVAH AEQQTVAAVL MVAQLTQRSV HICHVARKEE
1630 1640 1650 1660 1670 1680
ILLIKAAKAR GLPVTCEVAP HHLFLSHDDL ERLGPGKGEV RPELGSRQDV EALWENMAVI
1690 1700 1710 1720 1730 1740
DCFASDHAPH TLEEKCGSRP PPGFPGLETM LPLLLTAVSE GRLSLDDLLQ RLHHNPRRIF
1750 1760 1770 1780 1790 1800
HLPPQEDTYV EVDLEHEWTI PSHMPFSKAH WTPFEGQKVK GTVRRVVLRG EVAYIDGQVL
1810 1820 1830 1840 1850 1860
VPPGYGQDVR KWPQGAVPQL PPSAPATSEM TTTPERPRRG IPGLPDGRFH LPPRIHRASD
1870 1880 1890 1900 1910 1920
PGLPAEEPKE KSSRKVAEPE LMGTPDGTCY PPPPVPRQAS PQNLGTPGLL HPQTSPLLHS
1930 1940 1950 1960 1970 1980
LVGQHILSVQ QFTKDQMSHL FNVAHTLRMM VQKERSLDIL KGKVMASMFY EVSTRTSSSF
1990 2000 2010 2020 2030 2040
AAAMARLGGA VLSFSEATSS VQKGESLADS VQTMSCYADV VVLRHPQPGA VELAAKHCRR
2050 2060 2070 2080 2090 2100
PVINAGDGVG EHPTQALLDI FTIREELGTV NGMTITMVGD LKHGRTVHSL ACLLTQYRVS
2110 2120 2130 2140 2150 2160
LRYVAPPSLR MPPTVRAFVA SRGTKQEEFE SIEEALPDTD VLYMTRIQKE RFGSTQEYEA
2170 2180 2190 2200 2210 2220
CFGQFILTPH IMTRAKKKMV VMHPMPRVNE ISVEVDSDPR AAYFRQAENG MYIRMALLAT
VLGRF
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
11 N-termini - 11 C-termini - 8 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P27708-2-unknown | MAALVL... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P27708-2-Acetylation | AALVLE... | 2 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
P27708-2-Acetylation | AALVLE... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345 | ||
P27708-2-Acetylation | AALVLE... | 2 | acetylation- | other | CNRS/ISV | Large_scale_NTA_Human | |||
P27708-2-Acetylation | AALVLE... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345 | ||
P27708-2-Acetylation | AALVLE... | 2 | acetylation- | N-TAILS | Overall Laboratory | Lange_Huesgen_et_al-RBC | |||
P27708-156-unknown | RPLVPE... | 156 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17536 | |||
P27708-790-unknown | FDHTVK... | 790 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7397 | |||
P27708-792-unknown | HTVKPV... | 792 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11391 | |||
P27708-1101-unknown | AYTDGD... | 1101 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15326 | |||
P27708-1139- | AVASDG... | 1139 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
P27708-1139- | AVASDG... | 1139 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P27708-1139- | AVASDG... | 1139 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P27708-1139- | AVASDG... | 1139 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P27708-1144-unknown | GVVAAI... | 1144 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1764 | |||
P27708-1372-unknown | GECPPQ... | 1372 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1765 | |||
P27708-1439-unknown | ALGQIG... | 1439 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC3744 | |||
P27708-1455-unknown | CMTSQK... | 1455 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11392 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...LDPNAR | 155 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC17536 | |||
...ENCVGF | 789 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7397 | |||
...CVGFDH | 791 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11391 | |||
...AAMNVA | 1100 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15326 | |||
...AVASDG | 1143 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1764 | |||
...EEAVDG | 1371 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1765 | |||
...KLFVEA | 1438 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC3744 | |||
...KVHVDC | 1454 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11392 | |||
...CHVARK | 1617 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000414742 | |||
...YEVSTR | 1974 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000388740 | |||
...VLGRF | 2225 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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