Q14684: Ribosomal RNA processing protein 1 homolog B

General Information

Protein names	- Ribosomal RNA processing protein 1 homolog B - RRP1-like protein B
Gene names	RRP1B
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q14684

18 N-termini

7 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAPAMQPAEI QFAQRLASSE KGIRDRAVKK LRQYISVKTQ RETGGFSQEE LLKIWKGLFY
        70         80         90        100        110        120
CMWVQDEPLL QEELANTIAQ LVHAVNNSAA QHLFIQTFWQ TMNREWKGID RLRLDKYYML
       130        140        150        160        170        180
IRLVLRQSFE VLKRNGWEES RIKVFLDVLM KEVLCPESQS PNGVRFHFID IYLDELSKVG
       190        200        210        220        230        240
GKELLADQNL KFIDPFCKIA AKTKDHTLVQ TIARGVFEAI VDQSPFVPEE TMEEQKTKVG
       250        260        270        280        290        300
DGDLSAEEIP ENEVSLRRAV SKKKTALGKN HSRKDGLSDE RGRDDCGTFE DTGPLLQFDY
       310        320        330        340        350        360
KAVADRLLEM TSRKNTPHFN RKRLSKLIKK FQDLSEGSSI SQLSFAEDIS ADEDDQILSQ
       370        380        390        400        410        420
GKHKKKGNKL LEKTNLEKEK GSRVFCVEEE DSESSLQKRR RKKKKKHHLQ PENPGPGGAA
       430        440        450        460        470        480
PSLEQNRGRE PEASGLKALK ARVAEPGAEA TSSTGEESGS EHPPAVPMHN KRKRPRKKSP
       490        500        510        520        530        540
RAHREMLESA VLPPEDMSQS GPSGSHPQGP RGSPTGGAQL LKRKRKLGVV PVNGSGLSTP
       550        560        570        580        590        600
AWPPLQQEGP PTGPAEGANS HTTLPQRRRL QKKKAGPGSL ELCGLPSQKT ASLKKRKKMR
       610        620        630        640        650        660
VMSNLVEHNG VLESEAGQPQ ALGSSGTCSS LKKQKLRAES DFVKFDTPFL PKPLFFRRAK
       670        680        690        700        710        720
SSTATHPPGP AVQLNKTPSS SKKVTFGLNR NMTAEFKKTD KSILVSPTGP SRVAFDPEQK
       730        740        750
PLHGVLKTPT SSPASSPLVA KKPLTTTPRR RPRAMDFF

Isoforms

- Isoform 2 of Ribosomal RNA processing protein 1 homolog B

Sequence View

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Protein Neighborhood

Domains & Features

18 N-termini - 7 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q14684-1-unknown	MAPAMQ...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q14684-1-unknown	MAPAMQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt88254
Q14684-2-unknown	APAMQP...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q14684-2-unknown	APAMQP...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q14684-2-unknown	APAMQP...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162934
Q14684-2-	APAMQP...	2		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q14684-2-	APAMQP...	2		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14684-4-	AMQPAE...	4		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q14684-4-	AMQPAE...	4		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q14684-4-	AMQPAE...	4		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14684-4-	AMQPAE...	4		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q14684-4-	AMQPAE...	4		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q14684-4-	AMQPAE...	4		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q14684-4-	AMQPAE...	4		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q14684-4-unknown	AMQPAE...	4		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q14684-4-unknown	AMQPAE...	4	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160198
Q14684-276-unknown	GLSDER...	276	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172772
Q14684-276-	GLSDER...	276		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14684-386-unknown	CVEEED...	386		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q14684-386-unknown	CVEEED...	386	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160200
Q14684-387-unknown	VEEEDS...	387	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10294
Q14684-387-unknown	VEEEDS...	387	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151385
Q14684-458-unknown	SGSEHP...	458	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12260
Q14684-458-unknown	SGSEHP...	458	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152642
Q14684-489-	SAVLPP...	489		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q14684-489-unknown	SAVLPP...	489	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177921
Q14684-499-unknown	QSGPSG...	499	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7834
Q14684-499-unknown	QSGPSG...	499	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153217
Q14684-512-unknown	GSPTGG...	512	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10296
Q14684-512-unknown	GSPTGG...	512	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153341
Q14684-623-unknown	GSSGTC...	623	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14493
Q14684-623-unknown	GSSGTC...	623	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154647
Q14684-624-unknown	SSGTCS...	624	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4054
Q14684-624-unknown	SSGTCS...	624	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154666
Q14684-661-	SSTATH...	661		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q14684-661-unknown	SSTATH...	661	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169594

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SRVFCV	386	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10294
...SRVFCV	386	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134787
...STGEES	457	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12260
...STGEES	457	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136060
...PEDMSQ	498	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7834
...PEDMSQ	498	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136643
...PQGPRG	511	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10296
...PQGPRG	511	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136765
...QPQALG	622	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14493
...QPQALG	622	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138072
...PQALGS	623	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4054
...PQALGS	623	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138091
...AMDFF	758	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...AMDFF	758	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83872

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	386	VFCV.\|.VEEE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAB_HUMAN	457	GEES.\|.SGSE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CATS_HUMAN	498	DMSQ.\|.QSGP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAA_HUMAN	511	GPRG.\|.GSPT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAM_HUMAN	622	QALG.\|.GSSG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATB_HUMAN	623	ALGS.\|.SSGT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)